Indian Journal of Urology
LETTER TO EDITOR
Year
: 2022  |  Volume : 38  |  Issue : 1  |  Page : 78--79

Author Reply Re: Nerli RB, Ghagane SC, Rangrez S, Chandra S, Thakur ML, Gomella L. Detection of bladder cancer using voided urine sample and by targeting genomic VPAC receptors. Indian J Urol 2021;37:345-9


Rajendra B Nerli1, Shridhar C Ghagane1, Shadab Sadiq Rangrez2, Shreya Chandra3, Madhukar L Thakur4, Leonard Gomella5,  
1 Department of Urology, JN Medical College; Division of Urologic-Oncology, Urinary Biomarkers Research Centre, KLES Dr. Prabhakar Kore Hospital and Medical Research Centre, Belagavi, Karnataka, India
2 Department of Urology, JN Medical College, Belagavi, Karnataka, India
3 Division of Urologic-Oncology, Urinary Biomarkers Research Centre, KLES Dr. Prabhakar Kore Hospital and Medical Research Centre, Belagavi, Karnataka, India
4 Department of Urology; Department of Radiology, Thomas Jefferson University; The Sidney Kimmel Cancer Centre, Thomas Jefferson University, Philadelphia, PA, USA
5 Department of Urology, Thomas Jefferson University; The Sidney Kimmel Cancer Centre, Thomas Jefferson University, Philadelphia, PA, USA

Correspondence Address:
Rajendra B Nerli
Department of Urology, JN Medical College; Division of Urologic-Oncology, Urinary Biomarkers Research Centre, KLES Dr. Prabhakar Kore Hospital and Medical Research Centre, Belagavi, Karnataka
India




How to cite this article:
Nerli RB, Ghagane SC, Rangrez SS, Chandra S, Thakur ML, Gomella L. Author Reply Re: Nerli RB, Ghagane SC, Rangrez S, Chandra S, Thakur ML, Gomella L. Detection of bladder cancer using voided urine sample and by targeting genomic VPAC receptors. Indian J Urol 2021;37:345-9.Indian J Urol 2022;38:78-79


How to cite this URL:
Nerli RB, Ghagane SC, Rangrez SS, Chandra S, Thakur ML, Gomella L. Author Reply Re: Nerli RB, Ghagane SC, Rangrez S, Chandra S, Thakur ML, Gomella L. Detection of bladder cancer using voided urine sample and by targeting genomic VPAC receptors. Indian J Urol 2021;37:345-9. Indian J Urol [serial online] 2022 [cited 2022 May 18 ];38:78-79
Available from: https://www.indianjurol.com/text.asp?2022/38/1/78/334611


Full Text



We thank our esteemed readers for their interest in our recent article and appreciate the compliments expressed for our study. The follow-up group consisted of patients treated for nonmuscle invasive bladder cancer and were on routine follow-up. The follow-up consisted of ultrasonography, urine for cytology, and a white light cystoscopy. In patients with no obvious lesions, biopsies were randomly taken from previous scars, areas with hyperemia, and reddish areas. Use of postoperative mitomycin (within 6 h) is part of the departmental policy. Patients with high-grade lesions received bacillus Calmette–Guerin (BCG), and the first follow-up was done 3 months following completion of BCG instillation. None of the patients in the follow-up group had imaging-confirmed lesion, and routine cytology was negative.

VPAC receptor is nonspecific and that is why no patients with serum PSA >1.5 ng/mL were included to exclude patients with cancer of the prostate. Conventional cytology, fluorescence cytology, and histopathology were read by separate consultants. As suggested by Miyake,[1] false-positive results following 5-ALA cytology are probably due to pyuria or increased urinary white blood cells. Our preliminary study has small numbers and needs further confirmation following multicenter studies, with a larger study patient population. The study in our department is ongoing so as to create a large study group.

References

1Miyake M, Nakai Y, Anai S, Tatsumi Y, Kuwada M, Onishi S, et al. Diagnostic approach for cancer cells in urine sediments by 5-aminolevulinic acid-based photodynamic detection in bladder cancer. Cancer Sci 2014;105:616-22.