Indian Journal of Urology
: 2021  |  Volume : 37  |  Issue : 3  |  Page : 286--287

Skin nodules and proptosis in a case of carcinoma urinary bladder: An unusual presentation

Jeni Elizabeth Mathew1, Aditya Prakash Sharma1, Debajyoti Chatterjee2, Sudheer Kumar Devana1,  
1 Department of Urology, PGIMER, Chandigarh, India
2 Department of Histopathology, PGIMER, Chandigarh, India

Correspondence Address:
Aditya Prakash Sharma
Department of Urology, PGIMER, Chandigarh


Metastasis to the skin and orbit from bladder cancer is extremely rare. A 76-year-old diabetic male presented with skin nodules and proptosis of the left eye. Punch biopsy from the abdominal wall nodule showed malignant cells with perineural invasion. Immunohistochemistry showed features suggestive of metastatic urothelial carcinoma. We present this case of urothelial carcinoma of the urinary bladder presenting primarily with highly unusual nodular skin metastasis.

How to cite this article:
Mathew JE, Sharma AP, Chatterjee D, Devana SK. Skin nodules and proptosis in a case of carcinoma urinary bladder: An unusual presentation.Indian J Urol 2021;37:286-287

How to cite this URL:
Mathew JE, Sharma AP, Chatterjee D, Devana SK. Skin nodules and proptosis in a case of carcinoma urinary bladder: An unusual presentation. Indian J Urol [serial online] 2021 [cited 2022 Jun 29 ];37:286-287
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A 76-year diabetic male presented with firm, non-tender skin nodules on the upper abdomen, back and the scalp (above the right ear) and proptosis of the left eye for the past 3 months [Figure 1]a, [Figure 1]b, [Figure 1]c. He also had lower urinary tract symptoms without hematuria or dysuria. Routine blood investigations were normal. Punch biopsy from the abdominal wall nodule showed atypical pleomorphic cells with round nuclei, coarse chromatin, conspicuous nucleoli, and moderate amount of cytoplasm with perineural invasion. The following immunohistochemical markers were performed: Pan cytokeratin (CK), CK7, CK20, high molecular weight CK, Melan A, S100, GATA3, CDX2, CD45, and TTF1. Tumor cells were positive for pan CK, CK7, CK20, and GATA 3 and were negative for the rest, suggestive of metastasis from urothelial carcinoma [Figure 2]a, [Figure 2]b, [Figure 2]c, [Figure 2]d. Contrast-enhanced computerized tomography revealed a heterogeneously enhancing polypoid growth of size 4 cm × 3 cm in the urinary bladder [Figure 1]d along with enlarged lymph nodes along the bilateral iliac vessels. The patient was started on palliative chemotherapy (cisplatin based); however, he succumbed to the complications within 3 months of the diagnosis.{Figure 1}{Figure 2}

Liver, lungs, and bones are the most frequent sites of metastasis in genitourinary malignancies.[1] The reported incidence of cutaneous metastases from urothelial carcinoma is around 0.84%–3.6%.[2] Orbital metastases are also uncommon, accounting for 2.5%–8.1% of all the orbital space-occupying lesions.[3] Diminished vision, proptosis, decrease in mobility, and double vision are the most common manifestations of orbital metastases. This case highlights the unusual physical manifestations of the underlying urological malignancy. Grossly, the skin lesions vary morphologically from being nodular, as in our case, to inflammatory and fibrotic.[4] Combined expression of CK7 and CK 20 is found in around 89% of the cases.[5] A high index of suspicion and biopsy from the skin lesions are required to make the diagnosis of the underlying malignancy in a patient without hematuria. These cutaneous lesions portend a poor prognosis and are resistant to treatment.

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

Financial support and sponsorship: Nil.

Conflicts of interest: There are no conflicts of interest.


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