Indian Journal of Urology
ORIGINAL ARTICLE
Year
: 2018  |  Volume : 34  |  Issue : 1  |  Page : 34--38

Urodynamic outcomes of tamsulosin in the treatment of primary bladder neck obstruction in men


Manoj K Sudrania1, Anuj Deep Dangi2, Santosh Kumar2, Barath Kumar3, Nitin S Kekre2 
1 Department of Surgery, IQ City Medical College, Durgapur, West Bengal, India
2 Department of Urology, Christian Medical College, Vellore, Tamil Nadu, India
3 Department of Biostatistics, Christian Medical College, Vellore, Tamil Nadu, India

Correspondence Address:
Anuj Deep Dangi
Department of Urology, Christian Medical College, Vellore, Tamil Nadu
India

Introduction: Alpha blockers are widely used in the treatment of primary bladder neck obstruction; however, evidence for objective urodynamic efficacy is scarce. We studied the effect of the uroselective α1-blocker tamsulosin on urodynamic parameters in male patients with type I primary bladder neck obstruction. Methods: A single center prospective observational study was carried out from July 2013 to February 2015. Male patients (18–50 years) with type 1 primary bladder neck obstruction were recruited. Selected patients were started on tablet tamsulosin 0.4 mg once daily for 3 months. International prostate symptom score (IPSS), uroflow and urodynamic studies were done pre- and post-treatment. Primary outcome was decreased in minimum detrusor pressure at maximum flow rate by 15%. Wilcoxon-matched pair signed-rank test was used. Results: Of 39 patients recruited, 21 patients completed the follow-up as per protocol and were analyzed. Mean age was 41 years. 57% patients achieved the primary outcome (median detrusor pressure pre- and post-treatment were 71 and 56 cm of water, P < 0.001). Similarly, median values for bladder outlet obstruction index (BOOI) and IPSS decreased from 59 to 38 (P < 0.001) and 22 to 12 (P < 0.001), respectively. Median maximum flow rate increased from 8 to 10 ml (P = 0.05). Pretreatment BOOI of >60 was associated with poor outcomes. Conclusions: Tamsulosin 0.4 mg once a day is effective in reducing bladder outlet obstruction on pressure flow studies in patients with primary bladder neck obstruction type 1.


How to cite this article:
Sudrania MK, Dangi AD, Kumar S, Kumar B, Kekre NS. Urodynamic outcomes of tamsulosin in the treatment of primary bladder neck obstruction in men.Indian J Urol 2018;34:34-38


How to cite this URL:
Sudrania MK, Dangi AD, Kumar S, Kumar B, Kekre NS. Urodynamic outcomes of tamsulosin in the treatment of primary bladder neck obstruction in men. Indian J Urol [serial online] 2018 [cited 2021 Dec 6 ];34:34-38
Available from: https://www.indianjurol.com/article.asp?issn=0970-1591;year=2018;volume=34;issue=1;spage=34;epage=38;aulast=Sudrania;type=0