Indian Journal of Urology Users online:5792  
IJU
Home Current Issue Ahead of print Editorial Board Archives Symposia Guidelines Subscriptions Login 
Print this page  Email this page Small font sizeDefault font sizeIncrease font size


 
  Table of Contents 
LETTER TO EDITOR
Year : 2022  |  Volume : 38  |  Issue : 4  |  Page : 330
 

Author Reply Re: Sharma PK, Panaiyadiyan S, Kurra S, Kumar R, Nayak B, Kaushal S, et al. Association of human papillomavirus in penile cancer: A single-center analysis. Indian J Urol 2022;38:210


Department of Urology, Biochemistry and Pathology, All India Institute of Medical Sciences, New Delhi, India

Date of Submission30-Jul-2022
Date of Acceptance05-Sep-2022
Date of Web Publication1-Oct-2022

Correspondence Address:
Prabhjot Singh
Department of Urology, Biochemistry and Pathology, All India Institute of Medical Sciences, New Delhi
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/iju.iju_273_22

Rights and Permissions

 

How to cite this article:
Sharma PK, Panaiyadiyan S, Kurra S, Kumar R, Nayak B, Kaushal S, Sharma A, Kumar R, Seth A, Singh P. Author Reply Re: Sharma PK, Panaiyadiyan S, Kurra S, Kumar R, Nayak B, Kaushal S, et al. Association of human papillomavirus in penile cancer: A single-center analysis. Indian J Urol 2022;38:210. Indian J Urol 2022;38:330

How to cite this URL:
Sharma PK, Panaiyadiyan S, Kurra S, Kumar R, Nayak B, Kaushal S, Sharma A, Kumar R, Seth A, Singh P. Author Reply Re: Sharma PK, Panaiyadiyan S, Kurra S, Kumar R, Nayak B, Kaushal S, et al. Association of human papillomavirus in penile cancer: A single-center analysis. Indian J Urol 2022;38:210. Indian J Urol [serial online] 2022 [cited 2022 Dec 3];38:330. Available from: https://www.indianjurol.com/text.asp?2022/38/4/330/357733




We appreciate the author's interest in our recently published article on penile carcinoma (PeCa).[1] Regarding the query on telomerase activity in the control group, we did not find any difference in the telomerase activity between high-risk human papillomavirus (HPV)-infected and uninfected controls. Our study findings of higher telomerase activity in PeCa cases, which is insignificant with HPV-positivity status signals, telomerase activity is unaffected by HPV infection once the carcinogenesis sets in. However, the telomerase activity in HPV-affected cancers increases with the severity of the disease.[2] This was evident in the present study as the mean telomerase activity increased with the worsening of the tumor grade.

We also agree with the authors that further studies are warranted focussing on epigenetic alterations such as histone modifications, DNA methylation, and nonencoding RNAs after stratifying to different subtypes of PeCa for a better understanding of the role of HPV in PeCa.

Financial support and sponsorship: Nil.

Conflicts of interest: There are no conflicts of interest.



 
   References Top

1.
Sharma PK, Panaiyadiyan S, Kurra S, Kumar R, Nayak B, Kaushal S, et al. Association of human papillomavirus in penile cancer: A single-center analysis. Indian J Urol 2022;38:210.  Back to cited text no. 1
  [Full text]  
2.
Katzenellenbogen R. Telomerase induction in HPV infection and oncogenesis. Viruses 2017;9:180.  Back to cited text no. 2
    




 

Top
Print this article  Email this article
 

    

 
   Search
 
  
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
    Article in PDF (307 KB)
    Citation Manager
    Access Statistics
    Reader Comments
    Email Alert *
    Add to My List *
* Registration required (free)  


    References

 Article Access Statistics
    Viewed258    
    Printed16    
    Emailed0    
    PDF Downloaded26    
    Comments [Add]    

Recommend this journal