Indian Journal of Urology Users online:382  
Home Current Issue Ahead of print Editorial Board Archives Symposia Guidelines Subscriptions Login 
Print this page  Email this page Small font sizeDefault font sizeIncrease font size

  Table of Contents 
Year : 2019  |  Volume : 35  |  Issue : 2  |  Page : 173-174

Primary bilateral non-Hodgkin's lymphoma of the adrenal gland

Department of Paediatrics, Al-Kindy College of Medicine, University of Baghdad, Baghdad, Iraq

Date of Submission03-Dec-2018
Date of Acceptance15-Jan-2019
Date of Web Publication1-Apr-2019

Correspondence Address:
Mahmood Dhahir Al-Mendalawi
Department of Paediatrics, Al-Kindy College of Medicine, University of Baghdad, Baghdad
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/iju.IJU_359_18

Rights and Permissions


How to cite this article:
Al-Mendalawi MD. Primary bilateral non-Hodgkin's lymphoma of the adrenal gland. Indian J Urol 2019;35:173-4

How to cite this URL:
Al-Mendalawi MD. Primary bilateral non-Hodgkin's lymphoma of the adrenal gland. Indian J Urol [serial online] 2019 [cited 2023 Jan 28];35:173-4. Available from:


I have two comments on the interesting case report by Raoofziaee et al.[1] published in the October–December 2018 issue of the Indian Journal of Urology.

First, the authors described the clinical presentation, imaging findings, and histopathologic and immunohistochemical results as well as the chemotherapy plan of the primary bilateral non-Hodgkin's lymphoma (NHL) of the adrenal gland in a 38-year-old Iranian patient.[1] I assume that the rarity of this aggressive tumor occurring at an unusual site would have alerted the authors to take into consideration the possibility of impaired immune status in the studied patient. Among the conditions associated with defective immunity, human immunodeficiency virus (HIV) infection is paramount. My assumption is based on the following point. It is known that due to impaired immunity, co-infection with oncogenic viruses increases, and with increased life expectancy secondary to the use of antiretroviral therapy, patients with HIV infection are at greater risk to various kinds of tumors compared to immunocompetent individuals.[2] Among these tumors, NHL has been reported in patients infected with HIV.[3] In Iran, HIV infection is an evolving health hazard. Although no data are present on the current HIV seroprevalence in Iran, the available data suggest that the overall HIV rates have alarmingly increased by 80% per year for the past decade.[4] I assume that the authors did not consider the underlying HIV infection in the studied patient as the contemplated laboratory tests did not include HIV testing. I also assume that the contemplation of the diagnostic panel of blood CD4 lymphocyte count and viral overload measurements was envisaged in the studied patient. If that panel was done and it revealed HIV positivity, the case in question could be truly regarded a novel case report. This is because HIV-associated primary bilateral adrenal NHL has never been reported in the published literature to date.

Second, the pathogenesis of primary lymphoma of the adrenal gland is still a matter of research. The detection of the presence of both Epstein–Barr virus (EBV) and JC polyomavirus (JCV) genome sequences in biopsy specimens suggests the relevance of EBV and JCV co-infection in the pathogenesis of this rare type of tumors.[5] I assume that an attempt to detect EBV and JCV DNA sequences in the studied patient was also solicited.

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

Financial support and sponsorship


Conflicts of interest

There are no conflicts of interest.

   References Top

Raoofziaee M, Yarmohamadi A, Ahmadnia H. Primary bilateral non-Hodgkin's lymphoma of the adrenal gland. Indian J Urol 2018;34:300-2.  Back to cited text no. 1
[PUBMED]  [Full text]  
Valencia Ortega ME. Malignancies and infection due to the human immunodeficiency virus. Are these emerging diseases? Rev Clin Esp 2018;218:149-55.  Back to cited text no. 2
Busi Rizzi E, Schininà V, Cristofaro M, Bellussi A, Alba L, Bibbolino C, et al. Primary renal non-Hodgkin's lymphoma with inferior vena cava involvement: Report of one case in HIV-infected patient. Radiol Med 2002;103:279-82.  Back to cited text no. 3
Heidary M, Nasiri MJ. Why has HIV/AIDS prevalence increased in Iran? Clin Infect Dis 2016;63:846.  Back to cited text no. 4
Barzon L, Trevisan M, Marino F, Guzzardo V, Palù G. Primary bilateral adrenal B-cell lymphoma associated with EBV and JCV infection. Infect Agent Cancer 2009;4:1.  Back to cited text no. 5


Print this article  Email this article


    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
    Article in PDF (265 KB)
    Citation Manager
    Access Statistics
    Reader Comments
    Email Alert *
    Add to My List *
* Registration required (free)  


 Article Access Statistics
    PDF Downloaded68    
    Comments [Add]    

Recommend this journal