Indian Journal of Urology Users online:760  
Home Current Issue Ahead of print Editorial Board Archives Symposia Guidelines Subscriptions Login 
Print this page  Email this page Small font sizeDefault font sizeIncrease font size

  Table of Contents 
Year : 2014  |  Volume : 30  |  Issue : 4  |  Page : 443-444

Ureteritis cystica: A rare entity in children

1 Department of Urology, Hacettepe University School of Medicine, Ankara, Turkey
2 Department of Pathology, Hacettepe University School of Medicine, Ankara, Turkey

Date of Web Publication1-Oct-2014

Correspondence Address:
M Irfan Donmez
Department of Urology, Hacettepe University School of Medicine, S?hhiye 06100, Ankara
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0970-1591.139592

Rights and Permissions


Ureteritis cystica (UC) is a benign condition. Although it can often be diagnosed with imaging techniques, we report a case of a child for whom we planned nephrectomy and ureteral augmentation cystoplasty, but abandoned the cystoplasty due to extensive UC in the ureter.

Keywords: Augmentation cystoplasty, pathology, ureteritis cystica

How to cite this article:
Donmez M I, Beksac A T, Dogan H S, Koni A, Baydar DE, Tekgul S. Ureteritis cystica: A rare entity in children . Indian J Urol 2014;30:443-4

How to cite this URL:
Donmez M I, Beksac A T, Dogan H S, Koni A, Baydar DE, Tekgul S. Ureteritis cystica: A rare entity in children . Indian J Urol [serial online] 2014 [cited 2023 Jan 27];30:443-4. Available from:

   Introduction Top

Ureteritis cystica (UC) is a benign pathology, which develops following chronic inflammation. A variety of diseases with obstruction and chronic inflammation may lead to UC. Although a diagnosis is often made with imaging techniques, we report a case of a child in whom was discovered during a nephrectomy. To the best of our knowledge, this is the first pediatric case of UC.

   Case report Top

The patient was a 12 year old child who, as a newborn, had undergone surgery for anal atresia with rectourethral fistula repair and colostomy. His postnatal ultrasound (US) and Dimercaptosuccinic acid (DMSA) scan had shown a hypoplasic left kidney and bilateral minimal hydronephrosis. Voiding cystourethrography (VCU) showed bilateral grade 5 vesicoureteral reflux. At 1 year of age, the colostomy was closed and DMSA was repeated and differential function of the left kidney was found 22%, whereas the right kidney was 78%. In the 3 rd year of life, a second VCU revealed clinically significant residual urine, which required clean intermittent catheterization (CIC). He underwent bilateral Cohen ureteroneocystostomy for recurrent urinary tract infections (UTIs) under antibiotic prophylaxis. Ultrasound prior to surgery showed bilateral high grade hydronephrosis. On the follow-up, DMSA scan showed 63% differential function on the right kidney. At the age of 7, US showed persistent bilateral high grade hydronephrosis. When he became a 10-year-old, hemodialysis was initiated for the first time and he had been placed on a renal transplant waiting list. The patient was on CIC 6 times a day when another urodynamic evaluation was obtained at 12 years of age. The study revealed hypocompliant bladder with decreased anatomic capacity accompanying detrusor overactivity with no demonstrable vesicoureteric reflux. Due to the low functional bladder capacity, nephrectomy with ureteral augmentation cystoplasty was planned.

During surgery, after left simple nephrectomy, left ureter was dissected and spatulated, but ureteral mucosa was found to be filled with polyps [Figure 1]. It was decided not to use the ureter and the augmentation cystoplasty was postponed.
Figure 1: Innumerable 2-4 mm pearly raised vesicular/polipoid lesions covering entire mucosa of the ureter

Click here to view

Histopathological examination of the ureter showed polypoid ureteritis and exuberant UC producing exophytic mucosal lesions in a background of chronically inflamed lamina propria [Figure 2]. UC typically consisted of expanded cystic lesions containing colloid like eosinophilic fluid. Cysts were lined by flattened urothelial cells without atypia.
Figure 2: Florid ureteritis cystica with chronic inflammation in lamina propria. Large and small cysts lined by flattened urothelial cells leading to polipoid mucosal protrusions into the lumen; some filled with eosinophilic secretion ((a) H and E, ×40; (b) H and E, ×400)

Click here to view

   Discussion Top

Ureteritis cystica is a rare and benign pathology of inflammatory origin first reported by Morgagni in 1761 and described by Richmond and Robb in 1967. [1] It is the cystic transformation of von Brunn's nests. [2] A PubMed search with keywords of "ureteritis, cystica" revealed 72 papers those mostly presenting case reports without any pediatric age patients. Although many reports state female dominancy, Menendez et al. have reported this may not be true after evaluating 34 cases and showing only 44% of them being female patients. [3]

Ureteritis cystica is associated with chronic irritation. Some studies have shown nephrolithiasis and recurrent UTIs to be the cause. It is most frequently diagnosed incidentally. [1] UC is generally seen in patients during the evaluation of UTI (82%), urolithiasis (53%), and hematuria (52%). [4] Furthermore, it can present as renal colic. The differential diagnosis includes ureteral tumors, pseudodiverticula, urolithiasis, polyps, vascular indentations, tuberculosis, UTIs, and submucosal hemorrhages. [1] In the long-term, UC may result in an atrophic kidney due to obstruction.

In this particular case, the etiology was thought to be persisting recurrent UTIs initially due to the bilateral high grade reflux and then due to the obstruction that developed following antireflux surgery. Mahboubi et al. have reported UC in a patient who received formalin treatment for cyclophosphamide induced hemorrhagic cystitis. [5] Although, intravenous pyelography and retrograde urography were the preferred diagnostic tools earlier, in the last decade magnetic resonance and computed tomography urography have become more available and accurate. Despite advanced technology, imaging studies may be inadequate in some cases. Ureteroscopy is a definitive diagnostic approach in these cases [2],[3] In the present case, we did not have any imaging studies other than US since such pathology was not expected. Moreover, the patient's chronic renal failure precluded the use of imaging studies with contrast agents. Therefore, in such patients with history of chronic UTI, inflammation or obstruction, the possibility of this pathology should be taken into consideration and appropriate imaging modalities such as retrograde ureteropyelography or direct examination by ureterorenoscopy may be needed before reconstructive surgeries using the ureter. Limited data are present in the literature regarding follow-up and malignant transformation, however follow-up is advised annually. Duffin et al. have reported a case after follow-up of 17 years without malignant transformation, whereas there is a report of a case complicated with adenocarcinoma of the ureter. [4]

During the surgery we abstained from using this ureter as we did not have the facility of frozen section pathology and also had no experience of using such a ureter for augmentation. No bladder biopsies were taken during or after the surgery. The treatment of this pathology, which is believed to be reversible, depends on the elimination of the underlying causes.

   Conclusion Top

Ureteritis cystica is a rare pathology that should be considered in the presence of chronic inflammation and obstruction of the upper urinary tract. Presence of such pathology needs to be considered in cases undergoing ureterocystoplasty.

   References Top

1.Rothschild JG, Wu G. Ureteritis cystica: A radiologic pathologic correlation. J Clin Imaging Sci 2011;1:23.  Back to cited text no. 1
[PUBMED]  Medknow Journal  
2.Argüelles Salido E, Rodríguez Corchero J, López García MA, Pérez Espejo MP, Campoy Martínez P, Pena Outeiriño JM. Cystic ureteritis in a kidney transplantation candidate. Actas Urol Esp 2005;29:226-9.  Back to cited text no. 2
3.Menéndez V, Sala X, Alvarez-Vijande R, Solé M, Rodriguez A, Carretero P. Cystic pyeloureteritis: Review of 34 cases. Radiologic aspects and differential diagnosis. Urology 1997;50:31-7.  Back to cited text no. 3
4.Duffin TK, Regan JB, Hernandez-Graulau JM. Ureteritis cystica with 17-year followup. J Urol 1994;151:142-3.  Back to cited text no. 4
5.Mahboubi S, Duckett JN, Spackman TJ. Ureteritis cystica after treatment of cyclophosphamide-induced hemorrhagic cystitis. Urology 1976;7:521-3.  Back to cited text no. 5


  [Figure 1], [Figure 2]

This article has been cited by
1 Nephrogenic adenoma of the ureter in a teenager with history of leukemia
George Koberlein, Martha Munden
Radiology Case Reports. 2021; 16(6): 1384
[Pubmed] | [DOI]


Print this article  Email this article


    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
    Article in PDF (1,047 KB)
    Citation Manager
    Access Statistics
    Reader Comments
    Email Alert *
    Add to My List *
* Registration required (free)  

   Case report
    Article Figures

 Article Access Statistics
    PDF Downloaded168    
    Comments [Add]    
    Cited by others 1    

Recommend this journal