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Year : 2012  |  Volume : 28  |  Issue : 1  |  Page : 115

Zinc status in benign prostatic hyperplasia and prostate carcinoma

Wiwanitkit House, Bangkhae, Bangkok 10160, Thailand

Date of Web Publication12-Apr-2012

Correspondence Address:
Somsri Wiwanitkit
Wiwanitkit House, Bangkhae, Bangkok 1016. Thailand
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0970-1591.94974

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How to cite this article:
Wiwanitkit S, Wiwanitkit V. Zinc status in benign prostatic hyperplasia and prostate carcinoma. Indian J Urol 2012;28:115

How to cite this URL:
Wiwanitkit S, Wiwanitkit V. Zinc status in benign prostatic hyperplasia and prostate carcinoma. Indian J Urol [serial online] 2012 [cited 2023 Jan 27];28:115. Available from:


A recent publication on zinc status in benign prostatic hyperplasia and prostate carcinoma is very interesting. Christudoss et al. concluded that "BPH or prostate carcinoma may be associated with a reduction in the levels of tissue zinc, plasma zinc, and an increase in urine zinc/creatinine." [1] There are some facts to be concerned. First, it is still doubtful whether there is any confounding factor affecting the zinc status in the cases and controls. At least, the food source can be the important confounding factor. [2] Also, some underlying diseases, especially for diabetes mellitus, can result in lowering the blood zinc level. [3] In addition, some mutations that can be seen in the cancerous patients might affect the zinc status. Good examples are some recent reports that quoted "patients with TP53 mutant tumor had lower zinc levels than those with no mutation." [4],[5] Second, the technique for zinc determination should be clarified as there is no clear information on the technique. Different techniques such as colimetric methods and atomic spectrometry are available for zinc determination with differences in the details of analytical properties.

   References Top

1.Christudoss P, Selvakumar R, Fleming JJ, Gopalakrishnan G. Zinc status of patients with benign prostatic hyperplasia and prostate carcinoma. Indian J Urol 2011;27:14-8  Back to cited text no. 1
2.Gibson RS, Hess SY, Hotz C, Brown KH. Indicators of zinc status at the population level: A review of the evidence. Br J Nutr 2008;99 Suppl 3:S14-23.  Back to cited text no. 2
3.Fujimoto S. Studies on the relationships between blood trace metal concentrations and the clinical status of patients with cerebrovascular disease, gastric cancer and diabetes mellitus. Hokkaido Igaku Zasshi 1987;62:913-32.  Back to cited text no. 3
4.Dar NA, Mir MM, Salam I, Malik MA, Gulzar GM, Yatoo GN, et al. Association between copper excess, zinc deficiency, and TP53 mutations in esophageal squamous cell carcinoma from Kashmir Valley, India--a high risk area. Nutr Cancer 2008;60:585-91.  Back to cited text no. 4
5.Mir MM, Dar NA, Salam I, Malik MA, Lone MM, Yatoo GN, et al. Studies on Association Between Copper Excess, Zinc Deficiency and TP53 Mutations in Esophageal Squamous Cell Carcinoma From Kashmir Valley, India-A High Risk Area. Int J Health Sci (Qassim) 2007;1:35-42.  Back to cited text no. 5

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