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ORIGINAL ARTICLE
Year : 2010  |  Volume : 26  |  Issue : 4  |  Page : 497-501

Does angiotensin-converting enzyme polymorphism have association with symptomatic benign prostatic hyperplasia?


1 Endocrinology Division, Central Drug Research Institute, Lucknow-226 001, India
2 Division of Endocrinology, James Cancer Center, The Ohio State University, Columbus, OH 43210, USA
3 Pharmacology Division, Central Drug Research Institute, Lucknow-226 001, India
4 Chatrapati Sahuji Maharaj Medical University (CSMMU), Lucknow, India

Correspondence Address:
Vishwajeet Singh
Associate Professor, Department of Urology, CSMMU (Erstwhile KGMC), Lucknow 226003, UP
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0970-1591.74438

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Objectives : The aim of the study was to explore the putative significance of angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism and its correlation with the lower urinary tract symptoms (LUTS) in benign prostatic hyperplasia (BPH). Materials and Methods : ACE I/D polymorphisms were determined by polymerase chain reaction (PCR) in 200 patients with moderate to severe LUTS due to BPH and 200 patients of same age group without the LUTS having normal size prostate. ACE levels were estimated by spectrophotometer method. Logistic regression models were used to determine the genetic effects using SPSS statistical software (version 12.0). Results and Conclusions : The distribution of genotypes along with allelic frequency and carriage rate did not significantly differ between study and control groups. This study suggests that I/D polymorphisms within the ACE gene are not associated with the presence of LUTS in BPH patients. Future studies in large cohorts are needed that may reveal the spectrum of cellular mechanism mediated by ACE relevant to pathophysiology of BPH and effect of ethnic differences.


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