Indian Journal of Urology Users online:9557  
Home Current Issue Ahead of print Editorial Board Archives Symposia Guidelines Subscriptions Login 
Print this page  Email this page Small font sizeDefault font sizeIncrease font size

Year : 2010  |  Volume : 26  |  Issue : 2  |  Page : 301-302

Blue nevus of the prostate

1 Department of Pathology, Kasturba Medical College, Manipal, India
2 Department of Urology, Kasturba Medical College, Manipal, India

Date of Web Publication12-Jul-2010

Correspondence Address:
Ranjini Kudva
Department of Pathology, Kasturba Medical College, Manipal-576 104, Karnataka
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0970-1591.65411

Rights and Permissions


How to cite this article:
Kudva R, Hegde P. Blue nevus of the prostate. Indian J Urol 2010;26:301-2

How to cite this URL:
Kudva R, Hegde P. Blue nevus of the prostate. Indian J Urol [serial online] 2010 [cited 2022 Jul 3];26:301-2. Available from:

A 53-year-old man presented with history of dysuria. Clinical and radiological findings were compatible with benign prostatic hyperplasia. Serum PSA level was normal. Transurethral resection of prostate was performed. The specimen weighed 8 g and on histopathological examination disclosed glandular-stromal hyperplasia and extensive black pigmentation of the stroma. Stroma showed polygonal, elongated and fusiform cells with abundant brownish black granular pigment in the cytoplasm, obscuring the nucleus. The glandular epithelial cells were free of the pigment [Figure 1]. The pigment was negative for iron with the Perls' Prussian blue stain. The Fontana Masson silver impregnation for melanin was strongly positive. The pigment was bleached after treatment with potassium permanganate. These results suggest that the pigment in the stromal cells was melanin. The pigmented stromal cells stained with S-100 protein [Figure 2] and hence a diagnosis of blue nevus was rendered. The patient on follow-up after nine months was free of any disease.

   Discussion Top

Blue nevus is a rare lesion of dermal melanocytes. Although it usually occurs in the skin, it has been reported in other locations like oral mucosa, sclera, cervix, vagina and prostate. Blue nevus of the prostate is a rare lesion of dendritic melanocytes which may be found in the fibromuscular stroma. Melanin in the prostate was first documented by Nigogosyan and coworkers in 1963. [1] It was encountered in ovoid and elongated melanocytes in the fibromuscular stroma and designated blue nevus of the prostate owing to its similarity to the common blue nevus of prostate.

Melanocytic lesions of the prostate are exceedingly rare and may be found in three different forms- melanosis, blue nevus and malignant melanoma either primary or metastatic. Melanosis is a condition in which melanin is found in the stromal cells of the prostate and the glandular epithelium. [2] Melanosis has been reported in 0.07-10% of normal prostatic glands. [3] Blue nevi of the prostate are similar to those in the skin and are characterized by elongated fusiform melanin-containing cells in the stroma. [2] We have reviewed the literature and summarized the salient features in [Table 1]. It is important to remember that blue nevus can occur in the prostate so as not to misdiagnose them as malignant melanoma. Primary malignant melanoma is described in the prostate. [4] It is important that these lesions are carefully distinguished from cellular blue nevi to avoid over-diagnosis of malignancy.

The origin of melanocytes within the fibromuscular stroma of the prostate remains speculative. Rawles demonstrated that melanoblasts arise from the neural crest and migrate through the body until they reach their ultimate tissue site where they differentiate into recognizable melanocytes and the melanin is produced by melanocytes in the stroma. [2] Melanin in the glandular epithelium of the prostate as is seen in melanosis is thought to be the result of transfer of pigment from the adjacent stromal melanocytes into the glandular epithelium. [5],[6] Pigment which can be seen in prostatic epithelial cells unassociated with melanocytes has features of both melanin and lipofuchsin and hence represents an endogenous lipofuchsin-like cellular product rather than an example of melanogenesis by prostatic epithelial cells. [6]

It is clinically important to recognize blue nevus of prostate because this condition may closely simulate a malignant melanoma involving the gland. Blue nevus of the prostate may be overlooked because most often it is composed of small microscopic foci of relatively few pigmented cells in the fibromuscular stroma. [6]

   References Top

1.Nigogosyan G, Delapava S, Pickren JW, Woodruff MW. Blue nevus of the prostate gland. Cancer 1963;16:1097-9.  Back to cited text no. 1      
2.Langley JW, Weitzner S. Blue nevus and melanosis of prostate. J Urol 1974;112:359-61.  Back to cited text no. 2  [PUBMED]    
3.Block NL, Weber D, Schinella R. Blue nevi and other melanotic lesions of the prostate. report of three cases and review of the literature. J Urol 1972;107:85-6.  Back to cited text no. 3  [PUBMED]    
4.Grignon DJ, Ro JY, Ajala AG. Malignant melanoma with metastasis to adenocarcinoma of the prostate. Cancer 1989;63:196-8.  Back to cited text no. 4      
5.Aguilar M, Gaffney EF, Finnerty DP. Prostatic melanosis with involvement of benign and malignant epithelium. J Urol 1982;128:825-7.  Back to cited text no. 5  [PUBMED]    
6.Ro JY, Grignon DJ, Avala AG, Hogan SF, Tλtu B, Ordσnez NG. Blue nevus and melanosis of prostate. Electron-microscopic and immunohistochemical studies. Am J Clin Pathol 1988;90:530-5.  Back to cited text no. 6      


  [Figure 1], [Figure 2]

  [Table 1]

This article has been cited by
1 Pigmented lesion of the prostate [Lésion pigmentée de la prostate]
Bel Haj Salah, M. and Hergli, I. and Nechi, S. and Khanchel, F. and Khayat, O. and Chadly-Debbiche, A.
Annales de Pathologie. 2013; 33(1): 74-76
2 Lsion pigmente de la prostate
Mriam Bel Haj Salah,Ilhem Hergli,Saloua Nechi,Fatma Khanchel,Olfa Khayat,Achraf Chadly-Debbiche
Annales de Pathologie. 2013; 33(1): 74
[Pubmed] | [DOI]
3 Large Agminated Cellular Plaque-Type' Blue Nevus Surrounding the Ear: A Case and Review
P. Spring, P. Perrier, P. Erba, P. Hagmann, M.C. Mihm, D. Hohl
Dermatology. 2013; 227(1): 21
[Pubmed] | [DOI]
4 Non-epithelial neoplasms of the prostate
Gladell P Paner,Manju Aron,Donna E Hansel,Mahul B Amin
Histopathology. 2012; 60(1): 166
[Pubmed] | [DOI]
5 Non-epithelial neoplasms of the prostate
Paner, G.P., Aron, M., Hansel, D.E., Amin, M.B.
Histopathology. 2012; 60(1): 166-186


Print this article  Email this article
Previous article Next article


   Next article
   Previous article 
   Table of Contents
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
    Article in PDF (912 KB)
    Citation Manager
    Access Statistics
    Reader Comments
    Email Alert *
    Add to My List *
* Registration required (free)  

    Article Figures
    Article Tables

 Article Access Statistics
    PDF Downloaded111    
    Comments [Add]    
    Cited by others 5    

Recommend this journal