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Year : 2006  |  Volume : 22  |  Issue : 3  |  Page : 281-282

Outcome of valve ablation in late presenting posterior urethral valves

Department of Urology, SGPGIMS, Lucknow, India

Correspondence Address:
Naval Khurana
Department of Urology, SGPGIMS, Lucknow
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How to cite this article:
Khurana N, Agarwal S, Srivastava A. Outcome of valve ablation in late presenting posterior urethral valves. Indian J Urol 2006;22:281-2

How to cite this URL:
Khurana N, Agarwal S, Srivastava A. Outcome of valve ablation in late presenting posterior urethral valves. Indian J Urol [serial online] 2006 [cited 2022 Jul 2];22:281-2. Available from:

The Impact of Late Presentation of Posterior Urethral Valves on Bladder and Renal Function Orhan Z, Tayfun O, Haluk A, Esat K, Hasan Rand Taner K. J Urol 2006;175(5):1894-97.

   Summary Top

This retrospective study[1] between 1986 and 2004 included 106 patients with PUVs. Thirty-six boys (34%) were diagnosed after age five. Mean patient age at diagnosis was 8.8 years. Surgical management consisted of endoscopic valve ablation in 32 cases and vesicostomy with delayed valve ablation in four. Presenting symptoms, renal function and presence of vesicoureteral reflux and urinary tract infection were determined. Renal function was evaluated by plasma creatinine at presentation and during follow-up. Mean creatinine levels were compared to those in 51 patients with PUVs who had been diagnosed and treated before age five and followed regularly. Of the 36 patients 20 underwent urodynamic evaluation during follow-up. A total of 19 age-matched children with PUVs who were diagnosed before age five (mean 17.7 months) and underwent urodynamic evaluation during follow-up were selected as the control group. The most common symptoms at presentation were diurnal enuresis (47.2%) poor stream (19.4%) and urinary retention (13.9%). Overall, urodynamic bladder abnormalities were detected in 17 of 20 patients (85%). No significant difference in bladder capacity, compliance or postvoid residual was demonstrated between the late-presenting and control groups. Only detrusor overactivity was significantly lower in the late-presenting group. After a mean follow-up of 67.03 months age-specific creatinine levels were increased in 13 of 27 patients (48.1%), including 7 (25.9%) with ESRD. Renal function was significantly impaired in the late-presenting group compared to controls.

   Comments Top

Reports on the long-term follow-up after valve ablation of late-presenting PUV are scant.

Hendren[2] observed that PUVs are associated with a wide spectrum of obstruction. He graded the degree of obstruction on the basis of the secondary urinary tract changes. Early presentation was viewed as a poor prognostic sign and suggestive of a severe degree of obstruction. Late presentation suggested a lesser degree of obstruction with little clinical significance.

According to this retrospective study[1] late-presenting PUV had significantly impaired renal function and lesser incidence of detrusor overactivity in comparison to early-presenting PUV. The comparison group was not made up of all newborns when first diagnosed (mean age 18 months) and late late-presenting PUV had an average age of 8.5 years at the time of urodynamic evaluation. Therefore, the two groups do not offer a true contrast between early and late presentation.

IM.T. EL-Sherbeny et al[3] in their study of late-presenting PUV in 28 children (median age 3.5 years) depicted less favorable outcome of late-presenting PUV relative to those diagnosed in the first year after birth in respect to renal function and upper tract dilation. Similar were the results of some other studies too.[4],[5],[6]

Parkhouse et al[7] reviewed the renal function outcome in 98 boys with PUVs. Approximately two-thirds of the patients presented before one year of age and one-third after one year of age. Twenty-six (41%) of the 64 boys presenting before one year of age had a poor long-term outcome for renal function, in contrast to only five (15%) of 34 presenting after one year of age. The study also identified bilateral VUR at presentation as a poor prognostic factor.

There is a great deal of confusion regarding the prognosis of PUVs in relation to the age at presentation. If, on the one hand, one agrees with either Hendren[2] and Pieretti[8] that mild cases of PUVs occur in older children or with John Duckett[9] who proposed that many late-appearing valves were not obstructive, then late presentation is a good prognostic sign.

On the other hand this may be because most neonatal patients are those for whom there is little argument in diagnosis, but in a group with a later presentation will be included those patients in whom the diagnosis would lack unanimity. Early detection of PUVs by prenatal ultrasonography portends a poorer prognosis[7],[10] than that for those diagnosed in childhood. One must be careful not to equate "delay in diagnosis" with late presentation.[4] They are two distinct groups. We should redefine presentation as it relates to prognosis by the presentation. Those presenting with hydronephrosis on prenatal ultrasonography or with neonatal obstructive symptoms likely have a poorer prognosis than the group presenting later with urinary tract infection and enuresis. This latter group will have some patients with renal insufficiency but not the proportion that the early group has. There is a spectrum of PUV. The question is how each of us defines that spectrum.

   References Top

1.Ziylan O, Oktar T, Ander H, Korgali E, Rodoplu H, Kocak T. The impact of late presentation of posterior urethral valves on bladder and renal function. J Urol 2006;175:1894-7.  Back to cited text no. 1    
2.Hendren WH. Posterior urethral valves in boys. A broad clinical spectrum. J Urol 1971;106:298-307.  Back to cited text no. 2  [PUBMED]  
3.El-Sherbiny MT, Hafez AT, Shokeir AA. Posterior urethral valves: Does young age at diagnosis correlate with poor renal function? Urology 2002;60:335-8.  Back to cited text no. 3  [PUBMED]  [FULLTEXT]
4.Tejani A, Butt K, Glassberg K, Price A, Gurumurthy K. Predictors of eventual end stage renal disease in children with posterior urethral valves. J Urol 1986;136:857-60.  Back to cited text no. 4  [PUBMED]  
5.Lal R, Bhatnagar V, Mitra DK. Long-term prognosis of renal function in boys treated for posterior urethral valve. Eur J Pediatr Surg 1999;9:307-11.  Back to cited text no. 5  [PUBMED]  
6.Bomalaski MD, Anema JG, Coplen DE, Koo HP, Rozanski T, Bloom DA. Delayed presentation of posterior urethral valves: A not so benign condition. J Urol 1999;162:2130-2.  Back to cited text no. 6  [PUBMED]  
7.Parkhouse HF, Barratt TM, Dillon MJ, Duffy PG, Fay J, Ransley PG, et al. Long-term outcome of boys with posterior uretheral valves. Br J Urol 1988;62:59-62.  Back to cited text no. 7  [PUBMED]  
8.Pieretti RV. The mild end of the clinical spectrum of posterior urethral valves. J Pediatr Surg 1993;28:701-6.  Back to cited text no. 8    
9.Duckett JW. Editorial comment to: The mild end of the clinical spectrum of posterior urethral valves. J Pediatr Surg 1993;28:704-6.  Back to cited text no. 9    
10.Hutton KA, Thomas DF, Davies BW. Prenatally detected posterior urethral valves: Qualitative assessment of second trimester scans and prediction of outcome. J Urol 1997;1589:1022-5.  Back to cited text no. 10    


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