| RESEARCH ARTICLE |
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| Year : 2003 | Volume
: 20
| Issue : 1 | Page : 54-58 |
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Monotherapy with docetaxel in treatment of hormone resistant cancer of the prostate - our results
NK Mohanty, Vineet Malhotra, Rajiba L Nayak, RP Arora
Department of Urology, VM Medical College and Safdarjang Hospital, New Delhi, India
Correspondence Address:
N K Mohanty
C-II/124, Moti Bagh-1, New Delhi - 110 021
India
 Source of Support: None, Conflict of Interest: None  | Check |
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Objectives: Management of hormone resistant prostate cancer (HRCaP) is always a challenge to urologist. Microtubule inhibitors have been in focus as chemotherapeutic agents in carcinoma prostate, docetaxel being the most active among such drugs. The present study aims to evaluate the efficacy and safety of docetaxel as a single agent in the management of HRCaP.
Methods: Twenty patients of HRCaP between 58-82 years of age were enrolled to receive docetaxel 75mg/sq.m. intravenously every 3'd week with a minimum 6 dose schedule. A total number of 136 doses were used. All patients were D3 stage disease and symptomatic. Median prostate specific antigen (PSA) at the time of entry was 180ng/ml and the median follow up was for 28 months.
Results: An objective response in PSA reduction by = 80% was observed in 5 patients (25%) and more than 25% reduction seen in 12 patients (60%). Seventy percent of the patients showed improvement in symptoms on treatment. In 12 patients (60%), the disease was stable and showed response for a median period of 18 months. The median overall survival was 22 months. Adverse reaction in the form of anaemia, neutropenia, leucopenia was seen in 20 patients (100%), stomatitis, fever and alopecia was seen in 12 patients (60%). Four developed oral thrush (20%). Mortality occurred in 5 patients (25%) during the study, 2 died from pulmonary metastasis and 3 had cerebral metastasis with paraplegia.
Conclusions: The response seen in this study is very encouraging and suggests substantial durable activity of docetaxel as a single therapy in HRCaP |
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