Indian Journal of Urology Users online:2403  
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Year : 2003  |  Volume : 19  |  Issue : 2  |  Page : 125-128

Limited additional lateral biopsies improve the diagnostic accuracy of transrectal ultrasound guided sextant prostate biopsy

1 Department of Surgery, University of Nebraska Medical Centre, Omaha, Nebraska, USA
2 Department of Surgery, University of Missouri, Columbia, Missouri, USA

Correspondence Address:
K C Balaji
Director of Urological Oncology Research, Associate Professor, Urological Surgery, 982360, University of Nebraska Medical Center, Omaha. Nebraska 68198-2360
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Source of Support: None, Conflict of Interest: None

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We prospectively evaluated the need for routine use of additional lateral biopsies at the time of standard sextant prostatic biopsy to reduce the false negative rates. A total of 23 consecutive patients underwent 24 TRUS guided prostatic biopsies resulting in 246 biopsy cores. Prostate cancer was diagnosed in 8/24 (33.3%) biopsies. Although the age and prostate volume did not significantly differ between patients with or without cancer (p>O. 05), the pre­biopsy PSA and PSAD were significantly higher in pa­tients diagnosed with prostate cancer (p<0.05). Of the 8 patients diagnosed with prostate cancer 2/8 (25%) had cancer in the biopsies lateral to but not in the standard sextant biopsy sites. The additional lateral biopsies im­proved the sensitivity and negative predictive value of TRUS guided biopsy by 33.3% and 13% respectively. In conclusion, in spite of the small sample size in this study, prostate cancer detection is increased by 25% because of additional lateral biopsies at time of standard sextant prostatic biopsy.

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