| RESEARCH ARTICLE |
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| Year : 2003 | Volume
: 19
| Issue : 2 | Page : 117-119 |
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Total PSA and free PSA in patients with severe liver dysfunction
Rama Devi Mittal1, Mahendra Kumar Singh2, Charles Selvaraju1, Gourdas Choudhuri2
1 Department of Urology, SGPGIMS, Lucknow, India
2 Department of Gastroenterology, SGPGIMS, Lucknow, India
Correspondence Address:
Rama Devi Mittal
Department of Urology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareli Road, Lucknow 226 014
India
 Source of Support: None, Conflict of Interest: None  | Check |
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Objectives: To evaluate the effect of liver diseases in patients, on serum free prostate specific antigen (JPSA) levels, total prostate specific antigen (tPSA) levels and fPSA/tPSA ratios.
Methods: Serum concentrations of total and free as well as JPSA/tPSA were determined in 20 men with histologically confirmed liver cirrhosis, 15 men with chronic hepatitis and 20 healthy men.
Results: The serum levels of total PSA in liver cirrhosis as well as in chronic hepatitis were significantly lower than those observed in control. Free PSA remained unchanged.
Conclusions: Our study suggests that despite severe liver dysfunction the tPSA, fPSA as well as the ratio of fPSA/ tPSA were not elevated as it was hypothesized that liver impairment might affect the PSA levels, as liver is a site for PSA metabolism. |
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