| ORIGINAL ARTICLE |
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| Year : 2002 | Volume
: 19
| Issue : 1 | Page : 63-67 |
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Renal functional reserve in live related kidney donors
Monish Aron, SN Mehta, SC Tiwari, MG Karmarkar, Sandeep Guleria, Rekha Sharma
Departments of Urology, Surgical Disciplines, Nephrology & Laboratory Medicine, All India Institute of Medical Sciences, New Delhi, India
Correspondence Address:
Sandeep Guleria
Department of Surgical Disciplines, All India Institute of Medical Sciences, New Delhi - 110 029
India
 Source of Support: None, Conflict of Interest: None  | Check |
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Objectives: To determine the renal functional reserve in live related donors and compare it with that of normal controls.
Patients and Methods: The study group consisted of 12 subjects who underwent donor nephrectomy at our centre, more than 6 months prior to this study. The control group consisted of 12 healthy, age and sex-matched volunteers who had no previous history of renal disease. The test for renal, functional reserve consisted of a 2 hour baseline creatinine clearance followed by ingestion of 1.2 grains of protein per kg body weight, in the form of cooked red meat, over one hour: A subsequent 2-hour creatinine clearance starting one hour after the completion of protein load was done. Urine collections were meticulously supervised and serum creatinine levels were obtained at the midpoint of each urine collection.
Results: The rise in serum creatinine and creatinine clearance after protein loading was statistically significant in both donors and controls. The test used for estimation for renal, functional reserve was the percent change in creatinine clearance after an acute protein load. This was 26.9 % in the donor population and 29.6 % in the controls. The difference between the 2 groups, therefore, was not statistically significant.
Conclusions: The preservation of renal functional reserve implies that kidney donors are at no significant disadvantage compared to normal healthy people, by virtue of their kidney donation. |
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