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Year : 2002  |  Volume : 19  |  Issue : 1  |  Page : 63-67

Renal functional reserve in live related kidney donors

Departments of Urology, Surgical Disciplines, Nephrology & Laboratory Medicine, All India Institute of Medical Sciences, New Delhi, India

Correspondence Address:
Sandeep Guleria
Department of Surgical Disciplines, All India Institute of Medical Sciences, New Delhi - 110 029
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Source of Support: None, Conflict of Interest: None

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Objectives: To determine the renal functional reserve in live related donors and compare it with that of normal controls. Patients and Methods: The study group consisted of 12 subjects who underwent donor nephrectomy at our cen­tre, more than 6 months prior to this study. The control group consisted of 12 healthy, age and sex-matched vol­unteers who had no previous history of renal disease. The test for renal, functional reserve consisted of a 2 hour base­line creatinine clearance followed by ingestion of 1.2 grains of protein per kg body weight, in the form of cooked red meat, over one hour: A subsequent 2-hour creatinine clearance starting one hour after the completion of pro­tein load was done. Urine collections were meticulously supervised and serum creatinine levels were obtained at the midpoint of each urine collection. Results: The rise in serum creatinine and creatinine clear­ance after protein loading was statistically significant in both donors and controls. The test used for estimation for renal, functional reserve was the percent change in creati­nine clearance after an acute protein load. This was 26.9 % in the donor population and 29.6 % in the controls. The difference between the 2 groups, therefore, was not statisti­cally significant. Conclusions: The preservation of renal functional re­serve implies that kidney donors are at no significant dis­advantage compared to normal healthy people, by virtue of their kidney donation.

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