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Year : 1998  |  Volume : 14  |  Issue : 1  |  Page : 4-8

Chromosome 3p mosaicism in peripheral lymphocytes of sporadic renal cell carcinoma (RCC) patients and heir asymptomatic relatives

Department of Medical Oncology, Tata Memorial Hospital, Mumbai

Correspondence Address:
P SA Kadam
Department of Medical Oncology, Tata Memorial Hospital, Mumbai

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Source of Support: None, Conflict of Interest: None

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We performed cytogenetic analysis in peripheral lymphocytes of clinically diagnosed sporadic cases of RCC (Renal cell carcinoma) along with their asymptomatic first-degree relatives and age-matched normal controls. Of 10 patients, 8 showed a genetic mosaicism of 3p aberration and the affected locus was 3pl4p23. Surprisingly one offspring of a patient with 3p aberrations and two off springs of 2 other patients without 3p aberrations showed DNA lesions at the same locus 3p14p23. In conclusion, our findings in peripheral lymphocytes of RCC patients indicate the consistency of literature reports of tumour cytogenetics and supports the evidence of presence of RCC-related tumour suppressor genes at the region 3pl4p23. A genetic mosaicism observed in patient as well as asymptomatic relatives may be indicative of genetic susceptibility. However, these are preliminary observations based on a small number of patients and one needs to evaluate a substantial number of patients.

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