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Year : 1987  |  Volume : 3  |  Issue : 2  |  Page : 78-81

A comparative study of gentamicin pharmacokinetics in spinal cord-injured with incomplete spinal lesion and healthy adults.

Department of Urology, PGIMER, Chandigarh

Correspondence Address:
G C Malakondaiah
Department of Urology, PGIMER, Chandigarh

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Source of Support: None, Conflict of Interest: None

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Serum gentamicin concentrations were estimated by solid-phase radioimmunoassay before and 10, 20, 30, 60, 120, 240, 360 and 480 minutes after a bolus intravenous injection of gentamicin (1.5 mg/kg) in four patients with incomplete spinal lesion, within two weeks of spinal trauma and in four healthy adults. The serum levels showed a distinct distribution phase and an elimination phase. The serum gentamicin levels at 10 and 20 minutes in spinal injury cases were significantly higher than those of the controls (p less than 0.05; p less than 0.01 respectively). However, no significant difference was found in the volume of distribution (Vd), elimination rate constant (Kel), elimination half-life and clearance between the two groups. The significantly higher serum gentamicin levels in the spinal injury group during the distribution phase suggest differences in kinetic parameters of a peripheral compartments between the spinal cord-injured and the normal individuals.

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