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Year : 1987  |  Volume : 3  |  Issue : 2  |  Page : 60-63

Urethral response to thyrotropin-releasing hormone : a urodynamic study.

Department of Urology, PGIMER, Chandigarh

Correspondence Address:
S Vaidyanathan
Department of Urology, PGIMER, Chandigarh

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Source of Support: None, Conflict of Interest: None

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Thyrotropin releasing Hormone (TRH) produces an excitatory action on spinal motor neurons, besides interacting with the catecholaminergic system, opioids, substance P and 5-hydroxytryptamine. The effect of TRH (4 mg, i.v.) upon the urethra was investigated. Urethral pressure profilometry (UPP) was performed with Urolab 1154 in eight healthy males before, during intravenous infusion of normal saline, during infusion of TRH, and five minutes after the administration of TRH. The maximum urethral pressure (MUP) was 118 plus minus 13.66 cm H2O in the basal study, and 116 plus minus 13.44 cm H2O in the profilometry performed during infusion of normal saline (p greater than 0.2). Administration of TRH resulted in a significant increase in the MUP of 19.5 plus minus 6.84 cm H2O (p less than 0.05). The TRH-induced increase in MUP was short-lived and the UPP performed five minutes after TRH administration showed a significant decrease in the MUP (17.5 plus minus 6.93 cm H2O; p less than 0.05). TRH analogues which have a more potent central action and lower neuro-endocrine activity than TRH hold promise in the urological rehabiliation of selected cases of spinal cord injuries with sphincter incontinence.

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