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| Year : 1986 | Volume
: 3
| Issue : 1 | Page : 1-6 |
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Effect of acute and chronic ureteric ligation on renal blood flow.
R Kapoor, A Gulati, R Shukla, RP Sahi, RC Srimal
Department of Surgery, King George's Medical College, Lucknow
Correspondence Address:
R Kapoor
Department of Surgery, King George's Medical College, Lucknow
 Source of Support: None, Conflict of Interest: None  | Check |
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Alteration in total renal blood flow and its intra-renal distribution following acute or chronic ureteric obstruction was studied in dogs. The blood pressure, heart rate, ureteric pressure and renal blood flow of anaesthetised animals were recorded on a Grass polygraph using suitable catheters, transducers and preamplifiers. Regional renal blood flow was measured with the help of radioactive microspheres. The ureteric pressure started rising after its ligation and reached the peak at 24 hours and then declined steadily till 7 days. The total renal blood flow reached the peak at 90 mins followed by progressive decrease till 7 days following ligation. Total or regional blood flow did not change significantly in unobstructed kidney. In the obstructed kidney, a significant increase in blood flow occurred in zone IV (innermost cortex and juxtamedullary region) and a significant decrease occurred in zones I, II and III. Zone V showed no change. Heart rate and blood pressure were not significantly altered throughout the experiment. |
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